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目的:研究Survivin蛋白在非小细胞肺癌(NSCLC)中表达的临床意义。方法:运用免疫组化(IHC)方法检测51例NSCLC组织、21例癌旁组织和11例良性肺病变组织中Survivin的表达,并采用SPSS13.0软件进行统计分析。结果:Survivin在胞浆和/或胞核均有表达,其在NSCLC、癌旁和良性肺病变组织中的阳性率之间存在显著统计学差异(P<0.001),肿瘤组表达(76.5%,39/51)高于癌旁组织(19.0%,4/21)(P=0.000)。Survivin表达与分化程度有关(Ρ<0.05),其生存曲线及复发转移风险曲线均没有意义(Ρ>0.05)。多因素COX回归分析提示临床分期和复发转移状态为影响生存的因素。结论:Survivin可能与NSCLC的发生发展相关,还不能支持它作为判断预后和复发转移的指标。
Objective: To investigate the clinical significance of Survivin protein expression in non-small cell lung cancer (NSCLC). Methods: Survivin expression was detected by immunohistochemistry (IHC) in 51 cases of NSCLC, 21 cases of paracancerous tissues and 11 cases of benign lung lesions. SPSS 13.0 software was used for statistical analysis. Results: Survivin was expressed in both cytoplasm and / or nucleus. There was a significant difference (P <0.001) between the positive rate of Survivin and non-cancerous tissue in NSCLC tissues and benign lung lesions (76.5% 39/51) was higher than that in paracancerous tissues (19.0%, 4/21) (P = 0.000). The expression of Survivin was correlated with the degree of differentiation (P <0.05), and the survival curves and recurrence and metastasis risk curves were not significant (P> 0.05). Multivariate Cox regression analysis suggested that the clinical stage and the recurrence and metastasis status were the factors influencing survival. Conclusion: Survivin may be related to the occurrence and development of NSCLC, and it can not support it as an indicator of prognosis and recurrence and metastasis.