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目的了解光明医疗机构卫生消毒情况和消毒效果，提出改进措施，预防医院性传染病的传播。方法对2010年和2011年深圳市光明新区医疗机构消毒效果监测数据进行分析。结果2010-2011年监测总合格率为89.17%。2011年度合格率略高于2010年度，不同监测时间差异有统计学意义（P<0.01）；监测样品中，合格率最高的是无菌器械保存液和灭菌器生物监测，合格率均为100%，合格率最低的是医院污水，合格率为66.67%，不同类别样品合格率差异有统计学意义（P<0.01）；市级、区/街道级、私营、社康、个体医疗机构监测合格率分别为62.50%、94.19%、95.51%、95.46%和83.64%，差异有统计学意义（P<0.01）。结论深圳市光明新区消毒监测合格率呈上升趋势，但仍需增加监督监测频次，尤其对合格率较低的医疗机构和监测样本的监测。“,” [Objective] To understand disinfection effect in medical institutions at different levels in Guangming New District, provide effective improvement measures and prevent the prevalence of iatrogenic diseases. [Methods] Analysis was made on the sterilization monitoring data of medical institutions in Guangming New District, Shenzhen from 2010 to 2011. [Results] The overal passing rate in 2010~2011 was 89.17%. The qualified rate in 2011 was higher than in 2010, and there was a difference (P<0.01).Of the samples tested, the qualified rates of soaking solution of instrument and biological monitoring of sterilizer were the highest (100%), and the pol uted water in hospital was the lowest qualified rate 66.67%.There was a difference of the qualified rate in different samples (P<0.01). The qualified rate in medical institutions at city level, district/street level, community health service center, private and individual clinic was 62.50%, 94.19%, 95.51%, 95.46%, 83.64%. There was a difference (P<0.01). [Conclusion] The qualified rate of disinfection in medical institutions at different level was on an upward trend from 2010 to 2011, but the monitoring should be strengthened on the medical institutions and some disinfection objects which was low qualified rate.