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[目的]总结预防接种引起过敏性休克的临床特征、流行病学特点和应对措施。[方法]对1999~2008年国内文献报道的70例预防接种引起的过敏性休克病例进行分析。[结果]70例病人由17种疫苗引起,死亡5例。接种狂犬病疫苗、乙脑疫苗、乙肝疫苗引起的合计41例(占58.57%)。疫苗接种后<30min发生的占78.57%,30~60 min发生的占10.00%;>60 min发生的占11.43%;28例合并过敏性皮疹;5例有药物过敏史,2例有食物过敏史,1例有疫苗接种过敏史。[结论]单价多针次灭活疫苗是引起预防接种过敏性休克的主要疫苗品种。
[Objective] To summarize the clinical features, epidemiological characteristics and countermeasures of allergic shock caused by vaccination. [Methods] A total of 70 cases of anaphylactic shock caused by vaccination in our country from 1999 to 2008 were analyzed. [Results] 70 patients were caused by 17 kinds of vaccines, 5 died. Rabies vaccination vaccination, JE vaccine, hepatitis B vaccine caused a total of 41 cases (58.57%). 78.57% in 30 min after vaccination, 10.00% in 30-60 min, 11.43% in 60 min, 28 with allergic skin rash, 5 with history of drug allergy and 2 with history of food allergy , 1 case had a history of vaccination allergy. [Conclusion] Monovalent multi-dose inactivated vaccine was the main vaccine species that caused the prevention of anaphylactic shock inoculation.