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近年来,有报道称在美国境内发现饮用水和地表水中存在痕量水平的药物和其他不应存在的化学物质.由于这些被关注的新型污染物(CEC)通常处于很低的水平,因此需要检测的样品无法通过大规模的离线样品制备而得到.相比离线SPE(固相萃取),在线SPE具备许多为人熟知的优势.然而,在线SPE的安装非常复杂,需要使用多个泵用于上样和分析,还需要使用多个阀控制每个泵的流速.这样就增加了在线SPE的成本,也带来技术壁垒和潜在技术转移等问题.本文使用了一种集成阀和液体计量系统,将在线SPE与液相色谱三重四极杆质谱仪(LC/MS/MS)结合在一起.这
In recent years, there have been reports of trace levels of drugs and other non-existent chemicals found in drinking water and surface water in the United States, and since these new pollutants of interest (CECs) are often at very low levels, On-line SPE has many well-known advantages over off-line SPE (Solid Phase Extraction). However, the installation of online SPE is complicated and requires the use of multiple pumps for the upper Sample and analysis, but also need to use multiple valves to control the flow rate of each pump.This will increase the cost of on-line SPE, but also bring technical barriers and potential technology transfer.This paper uses an integrated valve and liquid metering system, Combine an on-line SPE with a liquid chromatography triple quadrupole mass spectrometer (LC / MS / MS).