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为了解孕期强化免疫对母血和脐血特异性抗体水平的影响 ,将门诊 4 8例孕 2 8～ 34周的孕妇平均分为研究组和对照组。研究组含服脊髓灰质炎活疫苗。临产前分别对两组孕妇抽取肘静脉血和产时取脐血 ,用间接ELISA法检测其抗脊髓灰质炎IgG抗体水平。结果 :研究组母血和脐血抗脊髓灰质炎IgG抗体水平明显高于对照组 ,两组脊髓灰质炎病毒Ⅰ、Ⅱ、Ⅲ型抗原在母血中产生的IgG抗体效价 1∶2 0 0 ,差异有显著性 (P <0 0 1) ;在脐血中产生IgG抗体效价 1∶4 0 0 ,也有显著性差异 (P <0 0 1)。提示孕妇强化免疫能增加母血和脐血中特异性抗体水平 ,对胎儿有一定的保护作用。
In order to understand the effect of the prenatal intensive immunization on the level of maternal blood and umbilical cord blood specific antibodies, pregnant women of 48 pregnant women at 28 to 34 weeks of pregnancy were divided equally into study group and control group. The study group contained a live poliomyelitis vaccine. Before labor, elbow vein blood and umbilical cord blood were collected from two groups of pregnant women, respectively, and their anti-polio IgG antibody levels were measured by indirect ELISA. Results: The level of anti-polio IgG in maternal blood and umbilical cord blood was significantly higher in the study group than in the control group. The titer of IgG antibodies in maternal blood of the two groups of poliovirus type I, II, and III antigens was 1: 200 (P <0.01). There was also a significant difference (P <0.01) in IgG antibody titer of 1: 400 produced in umbilical cord blood. Prompted pregnant women to strengthen immunity can increase the level of maternal blood and cord blood antibodies, the fetus has a certain protective effect.