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目的了解老年重症慢性阻塞性肺疾病(COPD)患者的呼吸道常见病原菌及其耐药性。方法选取150例老年重症COPD患者，检测常见呼吸道病原菌并测试其耐药性。结果共分离出178株病原菌，其中革兰氏阴性(G-)杆菌124株(69.7%)，其次是革兰氏阳性(G+)球菌33株(18.5%)，其余为真菌及病原菌混合感染。常见病原菌的耐药性较高。结论老年重症COPD患者呼吸道感染的常见病原菌种类多，耐药高。“,”Objective To understand the respiratory tract pathogens and their drug resistance of elderly severe chronic obstructive pulmonary disease (COPD) patients,and provide reference for clinical treatment.Methods 150 cases of elderly patients with severe COPD patients were included and respiratory pathogens and drug resistance from their sputum were detected. Results A total of 178 isolated pathogens were detected, including 124 Gram-negative (G-) bacil i(69.7%),fol owed by 33 Gram-positive(G+)cocci(18.5%),the rest were fungal pathogens and mixed infections.Some common pathogens showed high drug resistance.Conclusion Various pathogens and high drug resistance existed elderly COPD patients with severe respiratory infection.