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目的:研制甲基莲心碱脂质体,并对其体外性质进行考察。方法:采用薄膜分散法制备脂质体,利用正交实验对其处方进行优化对其形态、粒径、包封率及释药等体外性质进行考察。结果:甲基莲心碱脂质体形态规整,平均粒径为(842.5±4.65)nm,平均包封率为(72.8±1.5)%体外释药遵循Higuchi方程:Q=30.78t_(1/2)-5.12,(R~2=0.995),具有明显的缓释效果。结论:优化得到甲基莲心碱脂质体的处方及制备工艺,为进一步体内研究奠定了基础。
OBJECTIVE: To develop neferine liposomes and study their in vitro properties. Methods: Liposomes were prepared by membrane dispersion method. The orthogonal design was used to optimize the formulation of the liposomes. The morphology, particle size, encapsulation efficiency and drug release in vitro were investigated. RESULTS: The neferine liposomes had a regular shape and a mean diameter of (842.5 ± 4.65) nm with an average entrapment efficiency of (72.8 ± 1.5)%. The in vitro release followed the Higuchi equation: Q = 30.78t 1/2 (1/2) -5.12, (R ~ 2 = 0.995), with a significant sustained release effect. Conclusion: The prescription and preparation technology of neferine liposomes were optimized, which laid the foundation for further study in vivo.