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用严重缺碘病区的粮食喂养大鼠4个月,取生后不同日龄的仔鼠小脑,用免疫组化方法研究了神经元NSE的变化,进一步分析了甲功低下对脑发育的影响。实验结果表明:缺碘不仅引起了母鼠与仔鼠甲功低下,而且使仔鼠小脑发育受阻,表现为小脑外颗粒层增殖与消失延迟、分子层发育落后、NSE免疫阳性产物在分子层、内颗粒细胞层与髓质部位均减少,以致生后60日两组间NSE仍有差别。提示甲功低下通过NSE而影响小脑能量代谢,引起小脑发育障碍。
Cerebellum of rats of different ages after birth were fed with foodstuffs with severe iodine deficiency area for 4 months. The changes of NSE in neurons were studied by immunohistochemistry. The effect of hypothyroidism on brain development was further analyzed . The results showed that: iodine deficiency not only caused the mother and the offspring to lose the thyroid function, but also impeded the development of the cerebellum of the offspring. The results showed that the proliferation and disappearance of the extragranular granular layer were delayed, the development of the molecular layer lagged behind, the immunopositive products of NSE in the molecular layer, Within the granulosa cell layer and the medullary site were reduced, resulting in 60 days after birth NSE between the two groups are still different. Prompt low power through the NSE affect the cerebellar energy metabolism, causing cerebellar dysplasia.