抗肌球蛋白重链和轻链抗体在扩张型心肌病与冠心病鉴别诊断中的价值

• 机 构: 浙江省温岭市第一人民医院心内科;同济医科大学心血管病研究所
• 出 处: 中国现代医学杂志
• 发表日期: 1999年1期
• 关键词: DILATED CARDIOMYOPATHY CORONARY HEART DISEASE AUTOANTIBODY MYOSIN HEAVY CHAIN MY

目的:旨在探讨抗肌球蛋白重链和轻链抗体,在扩张型心肌病(DCM)和冠心病中鉴别诊断的价值.方法;对21例DCM患者,14例冠心病患者及正常健康组18例,进行临床免疫学检测,应用ELISA法、免疫转印法对检测数值进行分析.结果显示:ELISA法DCM患者阳性率43.9％,冠心病组28.6％,正常对照组均为阴性.免疫转印法21例的DCM患者阳性率43.9％,冠心组28.6％,正常对照组均为阴性.免疫转印法21例的DCM患者抗肌球蛋白重链抗体(200KD)10例阳性,阳性率47.6％,冠心组抗肌球蛋白轻链抗体(27.5KD)阳性4例,阳性率28.6％,PBS替代试验均为阴性.结论:抗心肌肌球蛋白重链和轻链的抗体检测有助于DCM和冠心病的鉴别诊断“,”Clinical immunological detection has performed in 21 patients with dilated cardiomyopathy(DCM),14 patients with coronary heart disease(CHD) and 18 healthy people in order to find out the role of antimyosin heavy and light chain in the differential diagnosis between DCM and CHD.ELISA and Immunoblot protein footprint were used for analysis.The results of using ELISA method showed that the positive rate of patients with DCM was 43.9%,of those with CHD was 28.6%and the normal control group was negative.Using p...