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目的探讨环氧合酶!2(COX!2)和核因子!kB(NF!kB)的阳性表达与胃癌的关系。方法应用免疫组织化学染色(SP法)分别检测106例活检标本中COX!2、NF!kB蛋白在人慢性浅表性胃炎、慢性萎缩性胃炎、不典型增生及胃癌组织中的表达情况。结果COX!2与NF!kB在胃癌中的表达明显高于在慢性浅表性胃炎、慢性萎缩性胃炎的表达(P<0.05),但与不典型增生的表达相比,无显著性差异(P>0.05)。COX!2与NF!kB在胃癌中的表达具有显著相关性(P<0.01)。结论COX!2与NF!kB与胃癌的发生有关,NF!kB有可能介导COX!2在胃癌中的表达。
Objective To investigate the relationship between cyclooxygenase-2 (COX! 2) and nuclear factor! KB (NF! KB) expression and gastric cancer. Methods Immunohistochemical staining (SP method) was used to detect the expression of COX! 2 and NF! KB proteins in human chronic superficial gastritis, chronic atrophic gastritis, atypical hyperplasia and gastric cancer in 106 biopsies. Results The expression of COX 2 and NF! KB in gastric cancer was significantly higher than those in chronic superficial gastritis and chronic atrophic gastritis (P <0.05), but not significantly different from that in atypical hyperplasia P> 0.05). There was a significant correlation between the expression of COX! 2 and NF! KB in gastric cancer (P <0.01). Conclusions COX! 2 and NF! KB are related to the occurrence of gastric cancer. NF! KB may mediate the expression of COX! 2 in gastric cancer.