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目的探讨异位错构瘤性胸腺瘤的临床病理特征及免疫学表型。方法对1例异位错构瘤性胸腺瘤进行临床病理学及免疫标记物表达情况观察。结果肿瘤有纤维性假包膜,由梭形细胞、上皮细胞、脂肪细胞及少量淋巴细胞构成,间质可见硬化胶原,血管均为薄壁中、小血管。免疫组化显示,上皮细胞及梭形细胞CKpan均弥漫(+),梭形细胞p63、calponin、SMA和vimentin亦(+),极少量上皮细胞AR(+),淋巴细胞CD3和CD20均部分(+),TDT(-)。结论异位错构瘤性胸腺瘤是主要发生于下颈部、边界清楚的良性肿瘤,认识其独特的临床病理形态特征、以及梭形细胞对上皮及肌上皮标记物的表达是正确诊断与鉴别诊断的关键。
Objective To investigate the clinicopathological characteristics and immunological phenotype of ectopic hamartoma. Methods One case of ectopic hamartoma was studied with clinicopathological and immunological markers. Results The tumor had a fibrous pseudocapsule. It consisted of spindle cells, epithelial cells, adipocytes and a few lymphocytes. The interstitial sclerosis was seen in the interstitium. The vessels were all thin-walled and small vessels. Immunohistochemistry showed that epithelial cells and spindle cells were diffuse (+), p63, calponin, SMA and vimentin (+), a very small amount of epithelial cells AR (+), lymphocytes CD3 and CD20 +), TDT (-). Conclusions Heterotopic hamartoma is a benign tumor mainly located in the lower neck and border. It is of great importance to recognize its unique clinicopathologic features and the expression of markers of epithelial and myoepithelial cells by spindle cells. The key to diagnosis.