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近来有人报道白血病和白血病前期(白期)患者骨髓培养比直接法揭示更多属于异常克隆的细胞。为了评价血液病患者骨髓细胞短期培养对发现染色体畸变的类型和频率的影响,作者将标准的直接法(经1～2小时孵育)和加或不加氨甲喋呤(MTX)培养1～4天的方法作比较。21例血液病患者的32次标本同时采用上述各种方法检查,结果显示:18次
Recently, it has been reported that bone marrow culture in patients with leukemia and preleukemia (white phase) revealed more cells belonging to abnormal clones than the direct method. To evaluate the effect of short-term culture of bone marrow cells from patients with hematological diseases on the type and frequency of chromosome aberrations found, the authors used the standard direct method (incubation for 1 to 2 hours) and methods with or without methotrexate (MTX) for 1 to 4 days. compared to. The 32 specimens of 21 patients with hematopathy were examined using the above methods. The results showed that: 18