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结核病(tuberculosis,TB)是由结核分枝杆菌感染引起,在全球由单一致病菌致死最多的慢性传染病。人类基因组学指出遗传易感性可能是影响宿主免疫功能和结核病发生、发展的因素之一,然而,基因多态性和环境因素共同影响了结核病的发病与转归。Cooper等[1]提出,γ-干扰素、白细胞介素(interleukin,IL)-12、IL-17、IL-23和IL-27等细胞因子在结核病免疫反应中起着关键作用。其中,IL-12作为促炎性细胞因子,与宿主抗结核分枝杆菌(mycobacteriumtuberculosis,MTB)感染的先天性和获得性免疫反应密切相关,在机体抗MTB感染过程
Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis infection, which is the most lethal cause of single pathogen in the world. Human genomics pointed out that genetic susceptibility may be one of the factors that affect host immune function and tuberculosis occurrence and development. However, genetic polymorphisms and environmental factors affect the incidence and outcome of tuberculosis. Cooper et al. [1] suggested that cytokines such as interferon-γ, interleukin (IL) -12, IL-17, IL-23 and IL-27 play key roles in tuberculosis immune response. Among them, IL-12 as a proinflammatory cytokine is closely related to the innate and adaptive immune response of the host to mycobacterium tuberculosis (MTB) infection. In the process of anti-MTB infection