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目的利用血压平滑指数评价缬沙坦与苯磺酸氨氯地平对轻、中度原发性高血压的降压作用。方法选取60例轻、中度原发性高血压患者,随机分成两组,分别给予缬沙坦和苯磺酸氨氯地平治疗,两组患者于治疗前后均进行24小时动态血压监测,分别计算血压平滑指数,并进行t检验和相关分析。结果两组患者经治疗后平均血压可达正常范围,缬沙坦组收缩压、舒张压的平滑指数显著高于苯磺酸氨氯地平组。结论缬沙坦较苯磺酸氨氯地平有更高的血压平滑指数,缬沙坦较苯磺酸氨氯地平在治疗轻、中度原发性高血压时降压作用更好,更平稳。
Objective To evaluate the antihypertensive effect of valsartan and amlodipine besylate on mild to moderate essential hypertension by using blood pressure smoothing index. Methods Sixty patients with mild to moderate essential hypertension were randomly divided into two groups and received valsartan and amlodipine besylate respectively. Both groups were monitored for 24-hour ambulatory blood pressure before and after treatment, and were calculated Blood pressure smoothing index, and t test and correlation analysis. Results After treatment, the average blood pressure in both groups reached the normal range. The smoothness index of systolic pressure and diastolic pressure in valsartan group was significantly higher than that of amlodipine besylate group. Conclusions Valsartan has a higher blood pressure smoothness index than amlodipine besylate. Valsartan is more effective and stable than amlodipine besylate in the treatment of mild to moderate essential hypertension.