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1988年以来,抗体基因工程的研究取得了一些技术上的进展。Huston等〔1〕和Bird等〔2〕利用基因工程技术成功制备了单链抗体(singlechainFvScFv或singlechainantigenbindingproteinSCA),scFv是由免疫球蛋白的重链可变区(VH)和轻链可变区(VL)通过一段连接肽连接而成的重组蛋白,它
Since 1988, research on antibody gene engineering has made some technical progress. Huston et al. [1] and Bird et al. [2] successfully produced a single chain FvScFv (single chain FvScFv or single chain antigen binding protein SCA) by using genetic engineering technology. The scFv is composed of the variable region (VH) and the light chain variable region (VL) of immunoglobulin. ) Recombinant protein linked by a linker peptide, it