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目的 提高肝门部胆管癌术后辅助化疗的治疗效果。方法 采用四甲基偶氮唑盐快速比色法对 2 5例手术切除的肝门部胆管癌新鲜标本作 8种临床常用化疗药物的敏感性测试。结果 该组织类型的肿瘤对抗癌药物的敏感性存在明显的个体差异。其中对表阿霉素的共同敏感率为 5 8% (14/2 4) ,阿霉素、卡铂均为 5 4% (13/2 4) ,顺铂为 5 0 % (12 /2 4) ,氟脲嘧啶为 17% (4/2 4) ,甲氨喋呤为 4% (1/2 4)。结论 应用化疗药物敏感性检测方法对肝门部胆管癌病人进行个体化选药 ,有利于提高术后的综合治疗效果。本组实验结果提示 ,在肝门部胆管癌的化疗中 ,蒽环类、铂化合物类抗肿瘤药可能是较为有效的。
Objective To improve the therapeutic effect of postoperative adjuvant chemotherapy for hilar cholangiocarcinoma. Methods The rapid colorimetry of tetramethyl azozolate was used to test the sensitivity of 25 clinically used chemotherapeutic drugs in 25 fresh specimens of hilar cholangiocarcinoma. Results There was a clear individual difference in the sensitivity of tumors of this tissue type to anticancer drugs. The common sensitivity rate to epirubicin was 58% (14/2 4), doxorubicin, carboplatin were 54% (13/2 4), and cisplatin was 50% (12/4) ) Fluorouracil was 17% (4/2 4) and methotrexate was 4% (1/2 4). Conclusion The use of chemotherapeutic drug sensitivity testing methods to individualize the patients with hilar cholangiocarcinoma will help improve the postoperative comprehensive treatment. The experimental results in this group suggest that anthracyclines and platinum compound anticancer drugs may be effective in the treatment of hilar cholangiocarcinoma.