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目的对高龄孕妇的胎儿染色体核型进行分析,对比不同年龄组与染色体异常情况的相关性。方法对1036例就诊的高龄孕妇进行羊膜穿刺术、羊水细胞培养并分析染色体核型。结果共检出异常核型69例,异常核型检出率为6.66%。在不同年龄组中,35-39岁、40岁及以上孕妇的羊水染色体异常检出率分别为5.70%、9.76%,差异具有统计学意义(P<0.05)。结论随着孕妇年龄增长,胎儿染色体异常率增加,对高龄孕妇进行产前诊断,指导临床干预具有重要意义。
OBJECTIVE: To analyze the fetal karyotype of pregnant women and compare the correlation between different age groups and chromosomal abnormalities. Methods A total of 1036 elderly pregnant women underwent amniocentesis, amniotic fluid cell culture and chromosome karyotype analysis. Results A total of 69 cases of abnormal karyotype were detected, the detection rate of abnormal karyotype was 6.66%. In different age groups, the detection rates of amniotic fluid chromosome abnormalities in 35-39 years old, 40 years old and above pregnant women were 5.70% and 9.76% respectively, the difference was statistically significant (P <0.05). Conclusion As the age of pregnant women increases, the rate of fetal chromosomal abnormalities increases, which is of great significance for the prenatal diagnosis of pregnant women and guiding the clinical intervention.