论文部分内容阅读
目的探讨肾小管间质损害在儿童肾小球肾炎进展中的临床及病理意义。方法选择44例肾小球肾炎患儿,对其临床及病理进行分析。结果肾小管间质损害轻度15例,中度20例,重度9例。随着肾小管间质损害程度的加重,患儿血压升高,尿蛋白定量增加,肾小球及肾小管功能减退。肾小管间质损害程度与血肌酐呈正相关;肾小球和血管的病变也加重,球性硬化加重;肾小管间质损害程度与球性硬化呈正相关。结论肾小管间质损害可能是决定儿童肾小球疾病进行性发展的关键因素之一。
Objective To investigate the clinical and pathological significance of tubulointerstitial lesions in children with glomerulonephritis. Methods Forty-four children with glomerulonephritis were selected and their clinical and pathological features were analyzed. Results Tubulointerstitial lesions were mild in 15 cases, moderate in 20 cases and severe in 9 cases. With the severity of tubulointerstitial damage, children with elevated blood pressure, urine protein increased, glomerular and tubular dysfunction. The degree of tubulointerstitial damage was positively correlated with serum creatinine. The glomerular and vascular lesions also aggravated, and the severity of sclerosis increased. The degree of tubulointerstitial damage was positively correlated with the degree of sclerosis. Conclusions Tubulointerstitial damage may be one of the key factors that determine the progressive development of glomerular disease in children.