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目的 观察复方丹参注射液治疗新生儿缺氧缺血性脑病(HIE)的疗效。方法在综合治疗的基础上应用复方丹参注射液治疗中、重度HIE 30例,并与单纯综合治疗组30例进行对照。结果 显效率和总有效率:治疗组为60％和90％,对照组为26.7％和66.7％,差异有显著性;20项新生儿神经行为评分正常率治疗组较对照组明显提高,差异有显著性;2组共随访 41例(78.8％),治疗组近期后遗症发生率低于对照组,差异有显著性;在丹参液的治疗过程中,未发现任何不良反应。结论 复方丹参注射液治疗HIE安全有效。
Objective To observe the curative effect of Fufang Danshen injection on neonatal hypoxic-ischemic encephalopathy (HIE). Methods 30 cases of moderate and severe HIE were treated with Fufang Danshen injection on the basis of comprehensive treatment, and compared with 30 cases of simple combination therapy group. Results The effective rate and total effective rate were 60% and 90% in the treatment group and 26.7% and 66.7% in the control group, respectively. There were significant differences between the two groups in the normal rate of neurobehavioral scores in the treatment group and the control group The incidence of sequelae in the treatment group was lower than that in the control group, the difference was significant; in the treatment of salvia miltiorrhiza, no adverse reactions were found. Conclusion Compound Danshen injection in the treatment of HIE is safe and effective.