丹参素、黄芩甙等对大鼠腹腔巨噬细胞产生PGE_2及TXB_2的影响

• 作 者: 张罗修 王梦 钱芸 曹致芳 梅美珍 易鸿匹
• 机 构: 上海医科大学药学院药理教研室,上海医科大学药学院药理教研室,上海医科大学药学院药理教研室,上海医科大学药学院药理教研室,上海医科大学药学院药理教研室,上海医科大学药学院药理教研室 上海 200032,
• 出 处: 中药药理与临床
• 发表日期: 1990年04期
• 关键词: 黄芩甙 鼠腹腔巨噬细胞 PGE_2 TXB_2 丹参素 角叉菜胶 硝苯吡啶 A_(23187) 大鼠 炎症刺激剂

酵母多糖刺激大鼠腹腔细胞合成与释放PGE_2及TXB_2,经短期培养(0～4h),静止的细胞合成的PGE_2虽随时间的延长而增加,但无显著差别,而TXB_2的增长有明显差别。经酵母多糖刺激后二者均有显著增加,但以TXB_2之增加更迅速。角叉菜、硅胶、钙离子载体A_(23187)均能显著促进培养24h的腹腔巨噬细胞合成与释放PGE_2和TXB_2。消炎痛、丹参素、硝苯吡啶及黄芩甙明显抑制A_(23187)诱导的PGE_2合成增加。

Yeast polysaccharide stimulated the synthesis and release of PGE 2 and TXB 2 in rat peritoneal cells. After short-term culture (0-4 h), PGE 2 synthesized by resting cells increased with time, but there was no significant difference, but there was a significant difference in TXB 2 growth. After stimulated by zymosan, both increased significantly, but the increase of TXB_2 was more rapid. Carrageenan, silica gel and calcium ionophore A_(23187) all significantly promoted the synthesis and release of PGE_2 and TXB_2 from peritoneal macrophages cultured for 24 hours. Indomethacin, danshensu, nifedipine and Huangqi significantly inhibited A_(23187)-induced increase in PGE 2 synthesis.