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以氧化修饰低密度脂蛋白攻击小鼠腹腔巨噬细胞为损伤模型，观察了云芝多糖对巨噬细胞泡沫样变性及衰减的影响的时效和量效关系。腹腔注射云芝多糖的小鼠腹腔巨噬细胞在体外与１０、５０、１００ｍｇ·Ｌ－１等三种浓度的氧化型低密度脂蛋白共同培养２４、４８和７２ｈ后，细胞形态未有较大改变，用ＭＴＴ比色法计数各时间点细胞存活数，受云芝多糖保护的巨噬细胞存活数较高。结果表明，云芝多糖能抑制巨噬细胞泡沫样变性，以及巨噬细胞泡沫样变性后，云芝多糖能延长其生存时间，防止其死亡，这对抑制动脉粥样硬化的进程有益处。
Oxidatively modified low-density lipoprotein challenged mouse peritoneal macrophages as a model of injury, and observed the time-effect and dose-effect relationship of P. yunnanensis polysaccharides on the foamy changes and attenuation of macrophages. In vitro peritoneal macrophages injected with P. yunnanense polysaccharides were co-cultured with oxidized LDL at concentrations of 10, 50, and 100 mg·L-1 for 24, 48, and 72 hours. The cell morphology was not large. The number of cell survival at each time point was counted by MTT colorimetry. The number of macrophages protected by P. oleracea polysaccharide was higher. The results showed that Yunzhi polysaccharide can inhibit macrophage foamy degeneration, and macrophage foam-like degeneration, Prunella polysaccharide can prolong its survival time, prevent its death, which is beneficial to inhibit the progression of atherosclerosis.