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本文报告严重充血性心力衰竭患者静脉输注Milrinone后电生理及血流动力参数的改变.受试者为56±10(42～77)岁的11例冠心病(8例)和特发性扩张型心肌病(3例)患者,心功能Ⅲ级(9例)或Ⅳ级(2例),试验前均无严重心律失常并停用心脏活性药物(利尿剂例外)至少5个半衰期.在5分钟内推注Milrinone50μg/kg;继而持续滴注48小时,速率为0.5μg/kg/min.其中1例推注Milrinone后血压急剧下降而须扩容治疗,未参加测试.滴注后18小时血药浓度为210±47ng/ml.同用药前相比,此时心脏指数增高(1.65±0.51～2.19±0.68L/min/m~2,p<0.03),肺毛细血管楔压
This article reports the electrophysiological and hemodynamic parameters after intravenous infusion of Milrinone in patients with severe congestive heart failure.The subjects were 11 coronary heart disease (n = 8) 56 years (range, 42-77) and idiopathic dilatation Cardiomyopathy (n = 3), grade III (n = 9), or normovolemia (n = 2), with at least 5 half-lives of no serious arrhythmia and discontinuation of cardiac active drugs (other than diuretics) Min bolus Milrinone 50μg / kg; followed by continuous infusion of 48 hours, a rate of 0.5μg / kg / min .Among them a sharp decline in blood pressure after bolus Milrinone expansion therapy, did not participate in the test 18 hours after instillation of blood drug Concentration of 210 ± 47ng / ml. Compared with before treatment, heart index increased (1.65 ± 0.51 ~ 2.19 ± 0.68L / min / m ~ 2, p <0.03), pulmonary capillary wedge pressure