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目的 :为探讨 1.6—二磷酸果糖 (FDP)治疗新生儿缺氧缺血性脑病 (HIE)的疗效。方法 :将 82例HIE患儿随机分为两组 ,治疗组 4 4例 ,对照组 3 8例 ,在常规治疗的基础上治疗组加用FDP ,2 5 0mg/kg ,快速静滴 ,Qd连用 5～ 7d。结果 :治疗组临床总有效率 4 1/ 4 4 ( 93 .2 % ) ,对照组总有效率 3 0 / 3 8( 78.9% ) ,两组有显著差异 (P <0 .0 5 )。结论 :外源性FDP能明显改善HIE患儿临床症状 ,促进心肌及脑细胞损伤的恢复 ,缩短病程 ,减少后遗症发生
Objective: To investigate the efficacy of fructose-1,6-diphosphate (FDP) in neonates with hypoxic-ischemic encephalopathy (HIE). Methods: Eighty-two children with HIE were randomly divided into two groups: 44 cases in the treatment group and 38 cases in the control group. On the basis of routine treatment, the patients in the treatment group were treated with FDP, 250 mg / kg, 5 ~ 7d. Results: The total effective rate was 41.4% (93.2%) in the treatment group and 30/38 (78.9%) in the control group, with significant difference between the two groups (P <0.05). Conclusion: Exogenous FDP can significantly improve the clinical symptoms of children with HIE, promote the recovery of myocardial and brain cell injury, shorten the course of disease and reduce the occurrence of sequelae