EFFECT OF ANTIBODIES AGAINST THE GAP JUNCTION PROTEIN ON DIFFERENTIATION OF INDUCED EMBRYONIC CELLS

• 作 者: 曾弥白 陈艳华
• 机 构: Shanghai Institute of Cell Biology, Academia Sinica,Shanghai Institute of Cell Biology, Academia Sin
• 出 处: Science in China,Ser.B
• 发表日期: 1988年11期
• 关键词: junction laevis induction rabbit dorsal IgG manipulator suggestion probes realiz

Microinjections of antibodies against gap junction prorein to early blastomcres of Xenopus laevis were succeeded by the treatments of mesodermal inductor. It was found that induction was not affected by the injection of the antibodies but the differentiation of notochord and muscle was impeded at different degrees. Cell interactions via gap junction communication seem to be involved in the differentiation of the induced cells.

Micro was injected antibodies against gap junction prorein to early blastomc of Xenopus laevis were succeeded by the treatments of mesodermal inductor. It was found that induction was not affected by the injection of the antibodies but the differentiation of notochord and muscle was impeded at different degrees. Cell interactions via gap junction communication seem to be involved in the differentiation of the induced cells.