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目的 探讨二氧化硅粉尘对人体作用中的脂质过氧化机制 ,寻求矽尘作业人员早期健康监测灵敏指标。方法 整群抽取 10 4名长期从事矽尘作业的采石工人和 10 1名无接尘、接毒史的健康工人为研究对象。分别测定血清中丙二醛 (MDA)、超氧化物歧化酶 (SOD)和谷胱甘肽过氧化物酶 (GSH Px)的含量并对其结果进行相应的统计分析。结果 接尘组血清MDA、SOD均高于对照组 ,而GSH Px则低于对照组 ,且均有统计学意义。 3项指标的异常检出率均高于对照组 ,其中MDA、SOD差异有显著性。接尘组MDA含量与SOD呈正相关 ,而与GSH Px呈负相关 ,3项指标均与累积接尘剂量有一定的相关。结论 二氧化硅粉尘可引起接触者体内脂质过氧化水平和抗氧化酶活性改变
Objective To investigate the lipid peroxidation mechanism of silica dust on human body and to seek the sensitive indicators for the early health monitoring of silica dust workers. Methods A total of 104 quarry workers who had been engaged in silica dusting operations and 101 healthy workers who had no dust and poisoned history were selected as the study objects. The contents of MDA, SOD and GSH Px in serum were determined and the results were analyzed statistically. Results The serum MDA and SOD in the dust-receiving group were higher than those in the control group, while the GSH Px was lower than that in the control group, and both were statistically significant. The abnormal detection rate of three indexes were higher than that of the control group, and the difference of MDA and SOD was significant. There was a positive correlation between the content of MDA and the SOD in the dust-receiving group, but negatively correlated with the GSH Px. All the three indexes were correlated with the accumulated dust-receiving dose. Conclusion Silica dust can cause changes of lipid peroxidation and antioxidant enzyme activity in contact subjects