Influence of Acetaminophen on Pharmacokinetics and Pharmacodynamics of Midazolam in Healthy Voluntee

• 作 者: Dennis Feierman Tunga Suresh M
• 机 构: DepartmentofAnesthesiology,DepartmentofAnesthesiology
• 出 处: 麻醉学期刊(英文)
• 发表日期: 2015年6期
• 关键词: MIDAZOLAM ACETAMINOPHEN BIS INDEX OAA/S SCORES MidazolamAcetaminophenBIS IndexOA

Background: Midazolam and acetaminophen are often co-administered in anesthesia practice. Both are metabolized by CYP 3A4 enzyme in the liver, and hence compete for the enzyme sites. This might lead to reduced metabolic breakdown and enhanced pharmacodyna