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目的:探讨丹参注射液联合MPT方案在降低多发性骨髓瘤患者血液黏滞度中的作用。方法:将52例多发性骨髓瘤患者随机分为两组:治疗组丹参注射液加MPT方案化疗27例,对照组MPT方案化疗25例,在治疗前后,比较临床症状改善情况,测定全血高切黏度、全血低切黏度、血浆黏度以及红细胞聚集指数,观察血液流变学相关指标的改变。结果:丹参注射液联合MPT方案治疗后患者血液流变学指标均不同程度降低。结论:在MPT方案治疗多发性骨髓瘤的同时应用丹参注射液,可降低血黏度,改善微循环。
Objective: To explore the effect of Danshen injection combined with MPT in reducing blood viscosity in patients with multiple myeloma. Methods: Fifty-two patients with multiple myeloma were randomly divided into two groups: treatment group, Salvia miltiorrhiza injection plus MPT regimen chemotherapy in 27 cases, control group MPT regimen chemotherapy in 25 cases, before and after treatment, to compare the clinical symptoms, the determination of whole blood high Shear viscosity, low shear viscosity of whole blood, plasma viscosity and erythrocyte aggregation index, observed changes of hemorheology related indicators. Results: The indexes of hemorheology of the patients treated with Danshen injection combined with MPT decreased to some extent. Conclusion: The treatment of multiple myeloma MPT program while the application of Salvia injection, can reduce blood viscosity, improve microcirculation.