宫腔内人工受精周期中使用重组卵泡刺激素与尿卵泡刺激素成本效益的比较:一项前瞻性随机研究

• 作 者: Gerli S. V. 侯巍
• 出 处: 世界核心医学期刊文摘(妇产科学分册)
• 发表日期: 2005年04期
• 关键词: 卵泡刺激素 人工受精 卵巢刺激 随机研究 临床妊娠率 成熟卵泡 促性腺激素 前瞻性随机试验 卵泡 佩鲁贾

To compare the clinical results and the cost effectiveness of urinary FSH and recombinant FSH in ovarian stimulation for IUI cycles. Prospective, randomized trial. University Hospital, Perugia, and A.G.UN.CO. Obstetrics and Gynaecology Centre, Rome, Italy. IUI cycles were performed in 67 infertile patients. Protocols of ovarian stimulation with urinary FSH or recombinant FSH were randomly assigned, for a total of 138 cycles performed (67 and 71, respectively). Number of mature follicles, days of stimulation, number of ampules, and IU used per cycle, biochemical/clinical pregnancy rates and costeffectiveness ratio. Follicular development, length of stimulation, pregnancy and delivery rates were not statistically different. Although in the urinary FSH group a significantly higher number of IU of gonadotropins were used (815.5 ±284.9 vs. 596.0 ±253.8), the cost per cycle remained significantly lower (220.73 ±94.72 vs. 318.50 ±125.21). The costeffectiveness ratio was 1,848.61 in the urinary FSH group and 2,512.61 in the recombinant FSH group. Urinary FSH and recombinant FSH are both effective in ovarian stimulation in IUI cycles. The urinary preparation is more cost effective due to the difference of its cost per IU.

To compare the clinical results and the cost effectiveness of urinary FSH and recombinant FSH in ovarian stimulation for IUI cycles. Prospective, randomized trial. University Hospital, Perugia, and AGUN.CO. Obstetrics and Gynecology Center, Rome, Italy. IUI cycles were performed in 67 infertile patients. Protocols of ovarian stimulation with urinary FSH or recombinant FSH were randomly assigned, for a total of 138 cycles performed (67 and 71, respectively). Number of mature follicles, days of stimulation, number of ampules, and IU used per cycle, biochemical / clinical pregnancy rates and costeffectiveness ratio. Follicular development, length of stimulation, pregnancy and delivery rates were not distinct different. Although in the urinary FSH group a significantly higher number of IU of gonadotropins were used ( 815.5 ± 284.9 vs. 596.0 ± 253.8), the cost per cycle was significantly lower (220.73 ± 94.72 vs. 318.50 ± 125.21). The cost-effective ratio was 1,848. 61 in the urinary FSH group and 2,512.61 in the recombinant FSH group. Urinary FSH and recombinant FSH are both effective in ovarian stimulation in IUI cycles. The urinary preparation is more cost effective due to the difference of its cost per IU.