Detection of promoter hypermethylation of Wnt antagonist genes in fecal samples for diagnosis of ear

• 作 者: Hu Zhang You-Qing Zhu Ya-Qiong
• 机 构: DepartmentofGastroenterologyandClinicalCenterofIntestinalandColorectalDiseasesofHubeiProvince,Depart
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2014年20期
• 关键词: COLORECTAL carcinoma SECRETED frizzled-related pro Colorectal carcinoma Secrete
• 基金项目: The National Natural Science Foundation of China,No.81101868,The Natural Science Foundation of Hubei Province of China,No.2011CDB505

AIM:To investigate the feasibility of detecting aberrantly hypermethylated Wnt-antagonist gene promoters(SFRP2 and WIF-1)in fecal DNA as non-invasive biomarkers for early colorectal cancer(CRC).METHODS:The methylation-specific polymerase chain reaction as