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甲氰咪胍已广泛用于治疗十二指肠溃疡。近有报告,每晚一次大剂量法可以预防溃疡复发。Dragsted认为夜间胃酸高分泌在十二指肠溃疡发病中是最重要的因素。作者发现,甲氰咪胍治疗后白天的胃内酸度个体差异很小,而治疗无效者夜间的胃内酸度几乎没有减低。这些资料提示,晚间一次较大剂量可作为本病有效的基本治疗。为此,作者比较每日两次或晚间一次甲氰咪胍或雷尼替丁治疗后24小时的胃酸变化。方法:经胃镜证实为十二指肠溃疡缓解期的患者12人。用随机单盲法,在5个不连续的24小时内,分别用安慰剂、甲氰咪胍400mgbid、800mgq.n、雷尼替
Cimetidine has been widely used to treat duodenal ulcers. Nearly reports, once a night high-dose method can prevent ulcer recurrence. Dragsted believes night nocturnal hypersecretion is the most important factor in the pathogenesis of duodenal ulcers. The authors found that individuals with intragastric acidity during the daytime after cimetidine treatment were small and that there was almost no reduction in intra-gastric acidity at night when treatment was ineffective. These data suggest that a larger dose at night can be used as the effective treatment of this disease. To do this, the authors compared gastric acid changes 24 hours after cidimetidine or ranitidine treatment twice daily or overnight. METHODS: Twelve patients with duodenal ulcer remission were confirmed by endoscopy. Randomized, single-blinded, placebo, cimetidine 400 mg bid, 800 mg q.n, ranitidine