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目的 :探索根除率较高、价廉、安全实用的HP根除方案。方法 :137例消化性溃疡或糜烂性胃窦炎患者 ,随机分为 3组 :A组 44例 ,以奥美拉唑 2 0mg +克拉霉素 2 5 0mg +替硝唑 5 0 0mg每天 2次 ,疗程 7天 ,即Bazzoli方案 ;B组47例 ,以奥美拉唑 2 0mg +阿莫西林 10 0 0mg +呋喃唑酮 10 0mg ,每天 2次 ,疗程 7天 ;C组 46例 ,以兰索拉唑 30mg每天 1次 ,阿莫西林 10 0 0mg +呋喃唑酮 10 0mg每天 2次 ,疗程 7天。活动期溃疡患者抗HP治疗后继服奥美拉唑 2 0mg或兰索拉唑 30mg ,每天 1次 ,3周。抗HP治疗结束 1月后复查胃镜并检测HP。结果 :A、B、C 3组的HP根除率分别为90 .9%、87.2 %和 89.1% ;活动期溃疡愈合率分别为 10 0 %、93 .8%和 10 0 % ;糜烂性胃窦炎愈合率分别为 85 .2 %、79.2 %和 92 .2 % ;副反应发生率分别为 13 .6 %、6 .4%和 8.7%。各组间差异无显著性 ,P >0 .0 5。A、B、C 3组每例抗HP所需费用分别为 5 44.5元、30 9.0元和 170 .5元。结论 :方案B、C是 2种新的、根除率较高、价廉、安全实用的HP根除方案
Objective: To explore a high eradication rate, cheap, safe and practical HP eradication program. Methods: One hundred and fourty-seven patients with peptic ulcer or erosive antral gastritis were randomly divided into three groups: 44 cases in group A, with omeprazole 20 mg + clarithromycin 250 mg + tinidazole 500 mg twice daily , Treatment for 7 days, the Bazzoli program; B group of 47 patients with omeprazole 20mg + amoxicillin 100mg + furazolidone 10mg, 2 times a day for 7 days; C group of 46 patients with Lan Sora Azole 30mg 1 day, amoxicillin 100mg + furazolidone 10mg 2 times a day for 7 days. Active ulcer patients after anti-HP treatment omeprazole 20mg or lansoprazole 30mg, 1 day, 3 weeks. After 1 month of anti-HP treatment endoscopy and examination of gastroscope HP. Results: The HP eradication rates in groups A, B and C were 90.9%, 87.2% and 89.1%, respectively. The healing rates of active ulcer were 100%, 93.8% and 100% respectively. Erosive gastric antrum The healing rates of inflammation were 85.2%, 79.2% and 92.2% respectively. The incidences of side effects were 13.6%, 6.4% and 8.7% respectively. No significant difference between the groups, P> 0.05. The cost of anti-HP in each of A, B and C 3 groups was 5 44.5 yuan, 30 9.0 yuan and 170.5 yuan respectively. Conclusion: B and C are two new types of HP eradication programs with high eradication rate, low cost, safe and practical