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本研究应用气相色谱法,测定了我国132位藏族和158位维吾尔族健康志愿者一次口服异喹胍(DB)10mg后8h尿中DB和4-羟异喹胍(4-OH-DB)的含量。结果表明,我国藏族和维族志愿者的DB羟化代谢均具双态性。求得藏及维族DB和4-OH-DB代谢比值的对数值(log MR)的范围分别为-0.70～1.54(MR为0.20～34.32)和-0.89～1.47(MR为0.13～29.73).以log MR=1.10为分界点,132位藏族和158位维族志愿者中分别有2个和1个弱代谢者。其缺陷频率分别为1.52和0.63%。吸烟和性别对DB羟化代谢的MR值无明显影响(P>0.2).服药后8h DB和4-OH-DB的回收率分别为:藏族19.83±10.99和10.81±6.58%;维族22.74±14.41和16.61±10.11%。
In this study, gas chromatography was used to determine the urinary DB and 4-OH-DB (8-OH-DB) in urine of 8 out of 132 Tibetans and 158 Uighur healthy volunteers after oral administration of 10 mg of DB. content. The results showed that all the Tibetan and Uighur volunteers in our country had bimorphs in the hydroxylation of DB. The log MR values for the Tibetan and Uighur DB and 4-OH-DB metabolic ratios ranged from -0.70 to 1.54 (MR 0.20 to 34.32) and -0.89 to 1.47 (MR 0.13 to 29.73) Log MR = 1.10 as the cut-off point, 132 Tibetans and 158 Uighur volunteers were 2 and 1 weak metabolizer. The defect frequencies were 1.52 and 0.63% respectively. Smoking and sex had no significant effect on the MR value of DB hydroxylation (P> 0.2). The recoveries of DB and 4-OH-DB at 8h after treatment were 19.83 ± 10.99 and 10.81 ± 6.58% for Tibetan and 22.74 ± 14.41 for Uygur And 16.61 ± 10.11%.