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最近,作者曾报道结核病病人下肢深静脉血栓形成(DVT)与其抗结核治疗有关。由于病人接受利福平的同时,又用大剂量华法令抗凝治疗,以致许多报道提出病人的出血问题。本文回顾性分析1978～1986年入院行结核病治疗的7542例成年病人。对照组选自1980～1987年入院诊断非结核病的肺脓肿或坏死性肺炎的成年病人.7542例病人中4391例(58.2%)采用利福平或包括利福平在内的联合用药方案(通常成人每日剂量为450或600mg),其中120例(2.7%)发生 DVT;未用利福平治疗的3151例病人中17例(0.5%)发生DVT(其相关危险系数为4.74,p<0.001)。而对照组252例肺脓肿病人中,只有1例发生 DVT(0.4%)。
Recently, the authors have reported that patients with tuberculosis have lower extremity deep vein thrombosis (DVT) associated with their anti-TB treatment. Due to patients receiving rifampicin at the same time, with a large dose of warfarin anticoagulant therapy, many reports raised the patient’s bleeding problems. This article retrospectively analyzed 7542 adult patients admitted to hospital for tuberculosis from 1978 to 1986. The control group was selected from adult patients diagnosed as having non-tuberculosis pulmonary abscess or necrotizing pneumonia from 1980 to 1987. Of the 7542 patients, 4391 (58.2%) received rifampicin or a combination regimen including rifampicin Adult daily doses were 450 or 600 mg), and DVT occurred in 120 (2.7%); DVT occurred in 17 (0.5%) of 3151 patients without rifampicin (hazard ratios 4.74, p <0.001 ). In the control group 252 patients with lung abscess, only 1 case of DVT occurred (0.4%).