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目的 :探讨胃癌癌前病变 ( PL GC) c- erb B- 2、P5 3基因蛋白的表达及胃炎消的治疗机制。方法 :以胃炎消治疗 19例 PL GC患者 ,采用 L SAB免疫组化法观察治疗前后 PL GC组织中 c- erb B- 2、P5 3蛋白的表达 ,并与维酶素治疗的 15例 PL GC患者作对照。结果 :c- erb B- 2及 P5 3蛋白在部分病例中有过表达 ,其表达随病变进展逐渐升高 ;胃炎消能一定程度地降低 c- erb B- 2蛋白的表达。结论 :胃炎消可能对 c- erb B- 2的表达有一定调节作用 ,但对 P5 3蛋白的表达作用不明显
Objective : To investigate the expression of c-erb B-2 and P53 gene protein in gastric precancerous lesions (PL GC) and the therapeutic mechanism of Weiyanxiao. Methods: 19 patients with PL GC were treated with Weiyanxiao. L SAB immunohistochemical method was used to observe the expression of c-erb B-2 and P53 protein in PL GC tissue before and after treatment, and 15 cases of PL GC treated with riboflavin. Patient as a control. RESULTS: c-erb B-2 and P53 protein were overexpressed in some cases. The expression of c-erb B-2 and P53 protein gradually increased with the progress of the disease. Gastritis energy-saving reduced the expression of c-erb B-2 protein to some extent. Conclusion: Weiyanxiao may regulate the expression of c-erb B- 2 , but its effect on the expression of P5 3 protein is not obvious.