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目的 研究急性脑卒中患者血浆因子Ⅶ（ＦⅦ）的变化。方法 用重组可溶性组织因子法测定ＦⅦａ，用ＥＬＩＳＡ法测定ＦⅦ：Ａｇ，用一阶段凝固法测定ＦⅦ：Ｃ。结果 出血性脑卒中与缺血性脑卒中的ＦⅦａ与ＦⅦ：Ｃ与对照组相比均明显升高（均Ｐ＜０．０５），缺血性卒中ＦⅦａ／ＦⅦ：Ａｇ比值较对照组增高（Ｐ＜０．０５）。结论 急性脑卒中病人血浆ＦⅦ升高明显，可能与动脉粥样硬化存在的高凝状态有关。
Objective To study the changes of plasma factor Ⅶ (FⅦ) in patients with acute stroke. Methods FⅦa was determined by recombinant soluble tissue factor method, FⅦ: Ag was determined by ELISA, and FⅦ: C was determined by one-stage coagulation assay. Results FⅦa and FⅦ: C in hemorrhagic stroke and ischemic stroke were significantly higher than those in control group (all P <0.05). The ratio of FⅦa / FⅦ: Ag in ischemic stroke was higher than that in control group P <0.05). Conclusions Acute stroke patients have obviously elevated plasma FⅦ, which may be related to the hypercoagulable state of atherosclerosis.