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目的和方法：观察了碱性成纤维细胞生长因子（ｂＦＧＦ）对异丙肾上腺素（ｉｓｏｐｒｏｔｅｒｅｎｏｌ，ＩＳＯ）引起的大鼠心肌坏死的拮抗作用及其机制。结果：ｂＦＧＦ明显减轻了ＩＳＯ引起的大鼠心肌坏死的程度，血浆ＬＤＨ、ＭＤＡ及心肌ＭＤＡ水平比单纯ＩＳＯ组动物分别降低２４８％、３２８％及２００％（Ｐ＜００１）；心肌胶原及心肌细胞线粒体钙含量分别降低１８２％及２０８％（Ｐ＜００５）；心肌ＡＴＰ含量增加３６７％（Ｐ＜００１）。结论：ｂＦＧＦ对ＩＳＯ引起的大鼠心肌坏死具有明显的保护作用，其机制与抗脂质过氧化及心肌细胞内钙超载有关。
PURPOSE AND METHODS: The antagonistic effect and mechanism of basic fibroblast growth factor (bFGF) on myocardial necrosis in rats induced by isoproterenol (ISO) were observed. Results: bFGF significantly reduced the degree of myocardial necrosis in rats induced by ISO, and the levels of plasma LDH, MDA and myocardial MDA decreased by 248%, 328% and 200%, respectively 01). The content of mitochondrial calcium in myocardial collagen and cardiomyocytes decreased by 182% and 208%, respectively (P <005), while the myocardial ATP content increased by 367% (P00101). CONCLUSION: bFGF has a significant protective effect on myocardial necrosis induced by ISO in rats. Its mechanism is related to anti-lipid peroxidation and intracellular calcium overload.