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目的探讨莫沙必利联合马来酸曲美布汀治疗反流性食管炎患者的临床疗效。方法选取2015年6月至2016年6月在大连港医院就诊的60例食管反流性食管炎患者为研究对象,按随机数字表法分为试验组与对照组,各30例。在抑酸、保护胃黏膜基础上对照组患者使用莫沙必利治疗,试验组患者在对照组基础上采用马来酸曲美布汀进行治疗,比较两组患者治疗后的生命质量和临床疗效。结果治疗后试验组患者角色功能、心理功能、躯体功能、社会功能评分及GQOLI-74总分均明显高于对照组,差异均有统计学意义(均P<0.05);两组患者治疗后有效率比较,试验组总有效率为96.7%,对照组总有效率为83.3%,试验组优于对照组,差异有统计学意义(P<0.05)。结论采用莫沙必利联合马来酸曲美布汀治疗反流性食管炎临床疗效显著。
Objective To investigate the clinical efficacy of mosapride and trimebutine maleate in the treatment of patients with reflux esophagitis. Methods Sixty esophageal reflux esophagitis patients treated in Dalian Port Hospital from June 2015 to June 2016 were selected as study subjects and divided into experimental group and control group according to the random number table method, with 30 cases in each group. The patients in the control group were treated with mosapride on the basis of acid suppression and gastric mucosa protection. The patients in the test group were treated with trimebutine maleate on the basis of the control group. The quality of life and clinical efficacy of the two groups were compared . Results After treatment, the role function, psychological function, physical function, social function score and GQOLI-74 score in the experimental group were significantly higher than those in the control group (all P <0.05). After treatment, Compared with the control group, the total effective rate was 96.7% in the test group and 83.3% in the control group, the difference was statistically significant (P <0.05). Conclusion The clinical effect of mosapride combined with trimebutine maleate in the treatment of reflux esophagitis is significant.