【摘 要】
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Desmoplastic small round cell tumor (DSRCT) is a rare,highly aggressive malignancy with distinctive histological features: a nesting patt of cellular growth wit
【机 构】
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Department of Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan, China“,”Department of Radiolog
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Desmoplastic small round cell tumor (DSRCT) is a rare,highly aggressive malignancy with distinctive histological features: a nesting patt of cellular growth within dense desmoplastic stroma, occurring in young population with male predominance. The mean survival period is only about 1.5-2.5 years. The tumor has co-expressed epithelial, muscle, and neural markers in immunohistochemical studies. This work reports a 27-year-old man presenting with hematemesis and chronic constipation.Serial studies including endoscopy, upper gastrointestinal series, abdominal computed tomography and barium enema study showed disseminated involvement of visceral organs. The patient underwent aggressive surgery and received postoperative adjuvant chemotherapy consisting of 5-fluorouracil, cyclophosphamide,etoposide, doxorubicin, and cisplatin. He survived without any disease for 20 mo after the surgery. No standard treatment protocol has been established. Aggressive surgery combined with postoperative multi-agent adjuvant chemotherapy is justified not only to relieve symptoms but also to try to improve the outcome in this advanced DSRCT young patient.
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