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目的应用异基因外周血干细胞移植 (allo PBSCT)对恶性血液病进行根治性治疗 ,观察造血重建及并发症情况。方法对一例急性淋巴细胞白血病完全缓解期的患者移植HLA完全相配的其胞兄外周血干细胞。移植单个核细胞合 7 14× 10 8/kg ,CFu GM 2 8.32× 10 4/kg。GVHD预防用短疗程MTX加小剂量CSA。结果术后 14天中性核细胞 >0 .5× 10 9/L(术后 15天 >2 .0× 10 9/L) ,BPC于术后 14天 >30× 10 9/L ,术后 2 0天显示骨髓造血重建 ,术后 17天经DNA位点检测表明移植物植入成功 ,无其它并发症及急性GVHD发生。结论本例allo PBSCT已获初步成功 ,显示其造血重建快的优点。
Objective To apply allogeneic peripheral blood stem cell transplantation (allo PBSCT) for radical treatment of hematologic malignancies and observe the hematopoietic reconstitution and complications. Methods A patient with complete remission of acute lymphoblastic leukemia was transplanted with his own sibling peripheral blood stem cells. Transplanted mononuclear cells combined 7 14 × 10 8 / kg, CFu GM 2 8.32 × 10 4 / kg. Short course of GVHD prophylaxis MTX plus low dose CSA. Results The number of neutrophils was> 0.05 × 10 9 / L (2.0 × 10 9 / L at 15 days after operation) and 30 × 10 9 / L at 14 days after operation 20 days bone marrow hematopoietic reconstructions showed, 17 days after the detection of DNA sites showed graft implantation, no other complications and acute GVHD. Conclusion This case of allo PBSCT has been initially successful, showing the advantages of rapid hematopoietic reconstitution.