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胃复安合成于1961年,是治疗消化系统疾病的常用药物。有关药理研究最早于1964年报道,以后报道渐多。应用此药可引起神经系统副作用,主要表现为锥体外系统症状。我院急诊科于1990年接诊因大剂量口服胃复安引起癫痫样表现2例。为引起同道重视,现结合文献报告如下。1 临床资料病例1,男性,13岁。因急性胃肠炎在当地诊所配胃复安100片,每片4mg。由于医嘱不清,患者自口服胃复安每天三次,每次12片(48mg);同时口服庆大霉素8万,每天两次。于口服胃复安三次后,突然跌倒,神志不清,口吐白沫,四肢抽搐,口唇青紫,约2分钟后自动停止。但约2小时后又出现上述症状。在当地医院诊断为癫痫。给安定10mg 肌注。此
Fufang Fu synthesis in 1961, is the treatment of digestive diseases commonly used drugs. The earliest pharmacological studies reported in 1964, after more reports. Application of this medicine can cause nervous system side effects, mainly manifested as extrapyramidal system symptoms. Our hospital emergency department in 1990 admissions due to high-dose oral metoclopramide caused epileptiform manifestations in 2 cases. In order to arouse the public’s attention, the present report is as follows. 1 clinical data cases 1, male, 13 years old. Due to acute gastroenteritis in the local clinic with metoclopramide 100 tablets, each 4mg. Due to unclear doctor’s advice, patients received oral metoclopramide three times a day, each of 12 tablets (48mg); at the same time oral gentamicin 80,000 twice daily. After three oral oral Fufang, suddenly fell, unconscious, foaming at the mouth, limbs twitch, lips bruising, about 2 minutes after the automatic stop. But about 2 hours later the above symptoms. Diagnosed with epilepsy at a local hospital. To stable 10mg intramuscular injection. this