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目的探讨胃癌卵巢转移机制。方法分别对1996年1月至2004年10月汕头大学医学院第一附属医院等单位32例胃癌卵巢转移原发灶、转移灶以及32例对照组(无卵巢转移)胃癌组织雌激素受体(ER)、孕激素受体(PR)和黏蛋白进行测定,结合临床病理资料分析。结果32例胃癌卵巢转移病例转移灶细胞分化程度明显低于原发灶(P<0.01);ER、PR组化染色、黏蛋白组化染色结果均显著高于原发灶(P<0.01)。32例胃癌卵巢转移病例原发灶和对照组胃癌在年龄、胃癌大体形态、病理组织学类型、ER、PR亲和组化染色、黏蛋白组化染色结果差异有显著性(P<0.01)。结论以“EER”为纽带的特殊的亲和性可能在胃癌卵巢转移中起到关键性作用;胃癌卵巢转移最主要的转移方式是淋巴转移(可以多种方式共存);黏蛋白显著增多是卵巢转移癌组织学分化程度下降的物质基础及其重要的临床表现。
Objective To investigate the mechanism of ovarian metastasis in gastric cancer. Methods From January 1996 to October 2004, 32 cases of primary gastric cancer metastasis and 32 cases of metastasis of gastric cancer and the control group (no ovarian metastasis) were recruited from the First Affiliated Hospital of Shantou University Medical College, respectively. The expressions of estrogen receptor ER), progesterone receptor (PR) and mucin were measured, combined with clinical and pathological data analysis. Results The differentiation degree of metastasis in 32 cases of gastric cancer with ovarian metastasis was significantly lower than that of the primary tumor (P <0.01). The results of ER, PR staining and mucin staining were significantly higher than those of the primary tumor (P <0.01). There were significant differences in the age, gastric cancer morphology, histopathological types, ER, PR affinity staining and mucin histochemical staining between the 32 cases with primary gastric cancer and the control group (P <0.01). Conclusion The special affinity of “EER” may play a key role in ovarian metastasis of gastric cancer. The most important metastasis of gastric cancer is lymphatic metastasis (coexistence of multiple ways); the increase of mucin is ovarian The material basis and important clinical manifestation of the decreased histological differentiation of metastatic carcinoma.