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目的：探讨慢性难愈合创面修复的非手术治疗。方法选取40例患者慢性难愈合创面共46处，控制基础疾病，局部清创，纳米银抗菌医用敷料保护创面及外用抗生素药物，防止感染或感染继续扩散，并合理使用碱性成纤维细胞生长因子或重组人表皮生长因子，期间辅以氦氖激光照射治疗。结果46处创面均痊愈，时间为1～3个月，治疗过程中未发生感染加重甚至侵袭性感染等情况。结论对于慢性难愈合创面，通过积极创面处理，辅以正确的创面用药及适当理疗，同样可以达到较理想的创面愈合。“,”Objective To study the non-surgical methods as the restorative treatment with refractory wounds. Methods Totally forty six refractory wounded sites have been selected from forty patients. We cleaned the wound-ed sites and applied both nano silver medical paste and antibiotics to prevent them from infectious spreading. Ad-ditionally, either alkaline ifbroblast growth factor or recombinant epidermal growth factor has also been applied on these sites, followed by further exposing them under the lights of He and Ne. Results All wounded sites have been healed within one to three months. There is no aggravating or invasive infections observed during the treatment. Conclusion Refractory wounds could be well healed by active handling directed on these sites with the help of proper dosing and physical treatment. This complex treatment procedure could achieve a prefect healing result.