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缺氧诱导因子(HIF)是一类重要的调节缺氧反应基因的转录因子,由HIF-1α和HIF-1β两种亚基组成,在多数肿瘤中表达增高,与肿瘤的生长及其肿瘤血管生成密切相关。在雌二醇诱导子宫内膜肿瘤血管的生成中,HIF-1α是重要的中介物,雌二醇可能通过HIF-1α诱导血管内皮生长因子表达发挥作用,进而促进子宫内膜肿瘤的发生。因此抑制HIF活性可能是治疗癌症的一种途径。
Hypoxia-inducible factor (HIF) is an important transcription factor that regulates hypoxia-responsive genes and consists of two subunits, HIF-1α and HIF-1β. HIF-1α is highly expressed in most tumors and correlates with tumor growth and tumor angiogenesis Generate closely related. HIF-1α is an important mediator in the estradiol-induced endometrial tumor angiogenesis. Estradiol may play a role in the expression of vascular endothelial growth factor induced by HIF-1α, which may promote the development of endometrial cancer. Therefore, inhibiting HIF activity may be a way to treat cancer.