Construction of Recombinant Plasmid Harboring APP717 Mutation and Preliminary Study of APP Proteolys

• 作 者: 李晓晴 薛峥 张苏明
• 机 构: DepartmentofNeurology
• 出 处: 华中科技大学学报：医学英德文版
• 发表日期: 2007年5期
• 关键词: 淀粉样蛋白 基因突变 阿尔滋海默病 重组质粒 APP C99 mutation Aβ YFP
• 基金项目: This project was supported by the Key Project of Chinese Ministry of Education （No. 10420）.

In order to investigate the pathogenesis of Alzheimer disease(AD) and study the enzymatic progress of amyloid precursor protein(APP),the fluorescent eukaryotic expression plasmid of C99 was constructed containing APP717 mutation.The fragment encoding the