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目的探讨妊娠期糖尿病(GDM)患者血清视黄醇结合蛋白4(RBP4)、内脂素水平变化的意义,研究视黄醇结合蛋白4和内脂素与胰岛素抵抗(IR)的相关性。方法采用稳态模型评估法评估正常糖耐量孕妇(NGT)、糖耐量减低孕妇(GIGT)和妊娠期糖尿病孕妇(GDM)的胰岛素抵抗指数,采用酶联免疫吸附法检测所有受试者的空腹血糖(FPG)、空腹胰岛素(FINS)、RBP4和内脂素水平。结果 GDM组和GIGT组血清RBP4、内脂素和胰岛素抵抗指数(HO-MA-IR)均显著高于NGT组(P<0.01)。血清RBP4、内脂素与HOMA-IR均呈显著正相关。结论妊娠期糖尿病患者存在胰岛素抵抗,RBP4、内脂素可影响妊娠期糖尿病患者IR的程度。
Objective To investigate the significance of serum retinol binding protein 4 (RBP4) and visfatin levels in patients with gestational diabetes mellitus (GDM) and to investigate the relationship between retinol binding protein 4, visfatin and insulin resistance (IR). Methods The insulin resistance index of normal glucose tolerance pregnant women (NGT), impaired glucose tolerance (GIGT) and gestational diabetes mellitus (GDM) were evaluated by steady-state model evaluation. The fasting blood glucose of all subjects was measured by enzyme-linked immunosorbent assay (FPG), fasting insulin (FINS), RBP4 and visfatin levels. Results Serum RBP4, visfatin and insulin resistance index (HO-MA-IR) in GDM group and GIGT group were significantly higher than those in NGT group (P <0.01). Serum RBP4, visfatin and HOMA-IR showed a significant positive correlation. Conclusion There is insulin resistance in patients with gestational diabetes mellitus, RBP4, visfatin can affect the degree of IR in gestational diabetes mellitus.