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A new and efficient synthetic route to hydroxymethylated-3,4-ethylenedioxylthiophene(EDOT-MeOH) was developed by a simple four-step sequence,and its global yield was approximately 41.06%.The poly(hydroxymethylated-3, 4-ethylenedioxylthiophene)(PEDOT-MeOH) film was electrosynthesized in aqueous sodium dodecylsulfate micellar solutions and characterized by different methods.The EDOT-MeOH possessed better water solubility,and lower onset oxidation potential than EDOT.The as-obtained PEDOT-MeOH film displayed good reversible redox activity,stability and capacitance properties in a monomer-free electrolyte,especially the good solubility of PEDOT-MeOH film in strong polar organic solvents such as dimethyl sulfoxide and tetrahydrofuran created a potential application in many different fields. Fluorescent spectra indicated that PEDOT-MeOH was a yellow-green-light-emitter with maximum emission at 568 nm.The as-formed PEDOT-MeOH film had good biocompatibility and was used for fabricating the electrochemical vitamin C biosensor.The proposed biosensor showed a linear range of 3×10~(-6) mol/L to 1.2×10~(-2) mol/L with the detection limit of 1μmol/L,a sensitivity of 95.6μA(mmol/L)~(-1) cm~(-2),and a current response time less than 10 s and a fairly good stability (The relative standard deviation was 0.43%for 20 successive assays,the proposed biosensor still retained 93.5%of bioactivity after 15 days storage.This result indicated that the prepared PEDOT-MeOH film as immobilization matrix of biologically-active species could be a promising candidate for the design and application of biosensor.
A new and efficient synthetic route to hydroxymethylated-3,4-ethylenedioxylthiophene (EDOT-MeOH) was developed by a simple four-step sequence, and its global yield was approximately 41.06%. The poly (hydroxymethylated-3, 4-ethylenedioxylthiophene) PEDOT-MeOH) film was electrosynthesized in aqueous sodium dodecylsulfate micellar solutions and characterized by different methods. EDOT-MeOH possessed better water solubility, and lower onset oxidation potential than EDOT. The as-obtained PEDOT-MeOH film displayed good reversible redox activity, stability and capacitance properties in a monomer-free electrolyte, especially the good solubility of PEDOT-MeOH film in strong polar organic solvents such as dimethyl sulfoxide and tetrahydrofuran created a potential application in many different fields. Fluorescent spectra indicated that PEDOT-MeOH was a yellow -green-light-emitter with maximum emission at 568 nm. The as-formed PEDOT-MeOH film had good biocompatibility and was used for fabricating the ele ctrochemical vitamin C biosensor. The proposed biosensor showed a linear range of 3 × 10 -6 mol / L to 1.2 × 10 -2 mol / L with the detection limit of 1 μmol / L, a sensitivity of 95.6 μA (mmol / L) ~ (-1) cm ~ (-2), and a current response time less than 10 s and a fairly good stability (The relative standard deviation was 0.43% for 20 successive assays, the proposed biosensor still retained 93.5 % of bioactivity after 15 days storage. This result indicated that the prepared PEDOT-MeOH film as immobilization matrix of biologically-active species could be promising candidates for the design and application of biosensor.