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目的:观察不同液体复苏对失血性休克大鼠肠粘膜的影响以及肠粘膜的变化。方法:利用大鼠失血性休克模型以及不同的补液方式,在复苏后120分钟时处死大鼠,取回肠4cm,做病理切片并根据Chiu等方法评估回肠黏膜上皮损伤指数。结果:液体复苏组的肠粘膜损伤程度小于休克不补液组(p<0.05),而限制型液体复苏组的肠粘膜损伤程度小于充分液体复苏组(p<0.05)。结论:通过本实验对肠粘膜的观察可以得出,对于失血性休克,液体复苏时有效的抗休克方式,而对于复苏的方式来说,从肠黏膜的保护方面来说,限制型液体复苏是优于传统的充分液体复苏的。
Objective: To observe the effects of different fluid resuscitation on the intestinal mucosa and the changes of intestinal mucosa in hemorrhagic shock rats. Methods: Rats were killed at 120 minutes after resuscitation by using hemorrhagic shock model of rats and different rehydration methods. The intestine was harvested 4 cm and pathological sections were made. The injury index of ileal mucosa epithelium was evaluated according to Chiu et al. Results: The intestinal mucosal lesion in liquid resuscitation group was less than that in shock resuscitation group (p <0.05), while the intestinal mucosal lesion in liquid resuscitation group was less than that in adequate liquid resuscitation group (p <0.05). CONCLUSIONS: The observation of the intestinal mucosa in this experiment shows that for hemorrhagic shock, an effective anti-shock regime for fluid resuscitation, and for the mode of recovery, limiting liquid resuscitation in terms of intestinal mucosal protection is Better than traditional full liquid resuscitation.