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近来,Norris及其同事报道心得安对先兆性心肌梗塞病人有保护作用。他们的报告重点论述了现代关于用β受体阻滞剂保护缺血心肌这一理论的飞跃发展。急性心肌梗塞的预后在某种程度上取决于梗塞灶的大小,并通过降低受损缺血组织的需氧量或者增加对其氧的供应则能改善梗塞灶,这一假说激起人们开始探讨保护缺血心肌的方法。无论是动物实验还是观察患者,结果都证明了在一定条件下的保护作用和梗塞范围和预后之间的相互关系。尽管应用降低心肌需氧量的药物(如三硝酸甘油脂,
Recently, Norris and colleagues reported that propranolol has a protective effect on patients with threatened myocardial infarction. Their report focuses on the modern development of the theory of beta-blocker protection of ischemic myocardium. The prognosis of acute myocardial infarction depends to some extent on the size of the infarct size and can improve infarct size either by reducing the oxygen demand of damaged ischemic tissue or by increasing its oxygen supply Methods of protecting ischemic myocardium. Whether in animal experiments or in patients, the results demonstrate the protective effect under certain conditions and the interplay between infarct size and prognosis. Although the use of drugs to reduce myocardial oxygen demand (such as trinitrate,