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目的研究肾脏的透析功能和调控机理。方法分别对肾小球毛细血管网和肾脏调控系统进行了数学建模。首先根据肾小球解剖结构建立肾小球小叶一维网络模型,然后基于前人工作,重建包括4个子系统(心血管系统、肾脏系统、激素系统、体液电解质系统)的肾脏调控系统数学模型,并将肾脏子系统部分与肾小球网络模型结合,模拟肾小球结构对过滤作用的影响。结果模拟了肾小球网络入球小动脉狭窄和有血管阻塞时各节点的压力、各血管的过滤流量以及人体快速摄入1 L水后尿液的排泄速率变化。结论模拟结果与实验结果基本符合,此模型可以用于对肾小球病变(血管狭窄,堵塞等)时的尿液排泄速率进行预测。
Objective To study the renal dialysis function and regulation mechanism. Methods The glomerular capillary network and renal regulation system were mathematically modeled. First of all, based on the anatomical structure of glomeruli, a one-dimensional network model of glomerular lobule was established. Based on the previous work, a mathematical model of kidney control system including four subsystems (cardiovascular system, renal system, hormonal system and humoral electrolyte system) The renal part of the system and glomerular network model combined to simulate the glomerular structure of the filtration effect. The results simulated the changes of urinary excretion rate in glomerular network after arterial stenosis and vascular obstruction, filtration fluxes in various vessels and rapid intake of 1 L water in human. Conclusion The simulation results are in good agreement with the experimental results. This model can be used to predict urinary excretion rate of glomerular lesions (vascular stenosis, occlusion, etc.).