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目的:比较III期非小细胞肺癌三维适形放疗(Three Dimensional Conformal Radiotherapy,3D-CRT)和调强放疗计划(Intensity Modulated Radiotherapy,IMRT)在靶区和危及器官上的剂量差异,为临床医生选择合适的放射治疗技术提供可靠的治疗依据。方法:选择16例III期非小细胞肺癌患者,采用Pinnacle V9.2治疗计划系统分别为每例患者设计3DCRT和IMRT两组放疗计划,分析比较两组计划的靶区适形度指标(Conformity Index,CI)和均匀性指数(Homogeneity Index,HI)以及正常组织的剂量分布。结果:IMRT和3D-CRT的靶区CI分别为0.97±0.02和0.91±0.04;HI分别为0.16±0.06和0.20±0.14,且差异具有统计学意义(P<0.05)。其余危及器官剂量参数,除肺组织V_5、V_(10)外,IMRT技术较3D-CRT技术均有不同程度的降低。结论:对于III期非小细胞肺癌的放射治疗,IMRT技术能够在提高靶区剂量的均匀性和适形度的同时,有效降低正常组织的受照剂量,从而降低患者放疗后并发症发生的可能性。
OBJECTIVE: To compare the dose differences between target volume and endangered organs in Three Dimensional Conformal Radiotherapy (3D-CRT) and Intensity Modulated Radiotherapy (IMRT) for stage III non-small cell lung cancer Appropriate radiotherapy techniques provide a reliable basis for treatment. Methods: Sixteen patients with stage III non-small cell lung cancer (NSCLC) were enrolled. Pinnacle V9.2 treatment planning system was used to design 3DCRT and IMRT radiotherapy plans for each patient. The planned conformability index (Conformity Index , CI) and Homogeneity Index (HI) as well as the normal tissue. Results: The CIs of IMRT and 3D-CRT were 0.97 ± 0.02 and 0.91 ± 0.04, respectively. The HI were 0.16 ± 0.06 and 0.20 ± 0.14, respectively, with statistical significance (P <0.05). In addition to the lung tissue V_5, V_ (10), IMRT technology than the 3D-CRT technology have different degrees of reduction. Conclusion: IMRT can effectively reduce the dose of normal tissue and reduce the possibility of post-radiotherapy complications in patients with stage III non-small cell lung cancer Sex.